General: Like other anti-platelet agents, Clopidogrel should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery or other pathological conditions. If a patient is to undergo elective surgery and an antiplatelet effect is not desired, Clopidogrel should be discontinued 7 days prior to surgery.
Hepatic or renal impairment: Should be avoided in patients with impaired hepatic and renal function. Aspirin causes sodium and water retention in patients with renal impairment, and increases the risk of gastrointestinal bleeding.
Use in Children: Safety and efficacy of Pedolip Plus in the paediatric population have not been established.